Trp53^tm3.1Wgu
Targeted Allele Detail

Summary

• Symbol: Trp53^tm3.1Wgu
• Name: transformation related protein 53; targeted mutation 3.1, Wei Gu
• MGI ID: MGI:6357928
• Synonyms: Trp53^KQ
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm3.1Wgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238814
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: All seven lysine codons in exon 11 were mutated to glutamine (p.K367Q, p.K369Q, p.K370Q, p.K378Q, p.K379Q, p.K383Q, p.K384Q) and a loxP site flanked neomycin resistance gene cassette was inserted into intron 10. Cre-mediated recombination removed the neo cassette. The mutant protein mimics the acetylated form of the protein. (J:238814)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 237 strains or lines available

References

• Original: J:238814 Wang D, et al., Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016 Oct 06;538(7623):118-122
• All: 4 reference(s)