E2f4^tm1.1Gle
Targeted Allele Detail

Summary

• Symbol: E2f4^tm1.1Gle
• Name: E2F transcription factor 4; targeted mutation 1.1, Gustavo Leone
• MGI ID: MGI:6357901
• Synonyms: E2F4^myc
• Gene: E2f4 Location: Chr8:106024295-106032002 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: E2f4^tm1.1Gle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276975
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag)
• Mutation: Insertion
• Mutation details: A 5x-myc tag was inserted just after the start codon in exon 1, a loxP site was inserted upstream of exon 2, and an FRT and loxP flanked neo cassette was inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:276975)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any E2f4 Mutation: 20 strains or lines available

References

• Original: J:276975 Cuitino MC, et al., Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation. Cell Rep. 2019 Jun 18;27(12):3547-3560.e5
• All: 1 reference(s)