Mapkapk2^tm1.2Gkl
Targeted Allele Detail

Summary

• Symbol: Mapkapk2^tm1.2Gkl
• Name: MAP kinase-activated protein kinase 2; targeted mutation 1.2, George Kollias
• MGI ID: MGI:6357679
• Synonyms: MK2^D, Mk2^delta
• Gene: Mapkapk2 Location: Chr1:130981437-131025563 bp, - strand Genetic Position: Chr1, 56.89 cM, cytoband E4
• Alliance: Mapkapk2^tm1.2Gkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262876
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The allele contains loxP sites 1/2 flanking a neomycin resistance gene fragment and loxP sites 2/3 flanking the area between exons 2-5. Cre-mediated recombination removed the selection cassette and exons 2 through 5. (J:262876)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapkapk2 Mutation: 36 strains or lines available

References

• Original: J:262876 Henriques A, et al., Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis. Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):E5546-E5555
• All: 1 reference(s)