Kcns1^tm1.1Kcl
Targeted Allele Detail

Summary

• Symbol: Kcns1^tm1.1Kcl
• Name: K+ voltage-gated channel, subfamily S, 1; targeted mutation 1.1, King's College of London
• MGI ID: MGI:6357176
• Synonyms: Kcns1 f
• Gene: Kcns1 Location: Chr2:164005539-164013033 bp, - strand Genetic Position: Chr2, 84.6 cM, cytoband H3
• Alliance: Kcns1^tm1.1Kcl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276188
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S7/SvEvBrd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette was inserted upstream of a floxed exon 3. Flp-mediated recombination removed the selection cassette and left exon 3 floxed. (J:276188)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcns1 Mutation: 29 strains or lines available

References

• Original: J:276188 Tsantoulas C, et al., Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity. Pain. 2018 Aug;159(8):1641-1651
• All: 1 reference(s)