Cd4^{tm1(Hbegf)Aox}
Targeted Allele Detail

Summary

• Symbol: Cd4^{tm1(Hbegf)Aox}
• Name: CD4 antigen; targeted mutation 1, Annette Oxenius
• MGI ID: MGI:6357154
• Gene: Cd4 Location: Chr6:124841655-124865184 bp, - strand Genetic Position: Chr6, 59.17 cM
• Alliance: Cd4^{tm1(Hbegf)Aox} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259080
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Cd4^{tm1(Hbegf)Aox} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• A floxed stop cassette followed by the primate gene was inserted into exon 2. (J:259080)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd4 Mutation: 83 strains or lines available

References

• Original: J:259080 Greczmiel U, et al., Sustained T follicular helper cell response is essential for control of chronic viral infection. Sci Immunol. 2017 Dec 1;2(18)
• All: 1 reference(s)