Pla2g4f^tm1Itl
Targeted Allele Detail

Summary

• Symbol: Pla2g4f^tm1Itl
• Name: phospholipase A2, group IVF; targeted mutation 1, Ingenious Targeting Laboratory
• MGI ID: MGI:6356866
• Gene: Pla2g4f Location: Chr2:120130438-120144646 bp, - strand Genetic Position: Chr2, 60.31 cM
• Alliance: Pla2g4f^tm1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278285
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The single loxP site was inserted upstream of exon 12, and the loxP/FRT-flanked Neo cassette inserted downstream of exon 12. The target region is 2.2 kb including exon 12. Exon 12 contains the active site residues Ser-393 and Arg-365. (J:278285)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g4f Mutation: 43 strains or lines available

References

• Original: J:278285 Yun B, et al., Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. J Biol Chem. 2014 Jan 17;289(3):1491-504
• All: 1 reference(s)