Cdk4^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Cdk4^tm1.1Cya
• Name: cyclin dependent kinase 4; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:6356824
• Synonyms: cdk4^flox, Cdk4^tm1.1Cgen
• Gene: Cdk4 Location: Chr10:126899404-126903157 bp, + strand Genetic Position: Chr10, 74.5 cM, cytoband D3
• Alliance: Cdk4^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230033
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 2-7. An frt-flanked neomycin selection cassette was also inserted in intron 7, but was subsequently removed via FLP-mediated recombination in the germline. (J:230033)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk4 Mutation: 57 strains or lines available

References

• Original: J:230033 Lagarrigue S, et al., CDK4 is an essential insulin effector in adipocytes.[RETRACTED]. J Clin Invest. 2016 Jan;126(1):335-48
• All: 2 reference(s)