Atp7b^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Atp7b^tm1.1Itl
• Name: ATPase, copper transporting, beta polypeptide; targeted mutation 1.1, Ingenious Targeting Laboratory
• MGI ID: MGI:6356804
• Synonyms: Atp7b^Lox
• Gene: Atp7b Location: Chr8:22482801-22550321 bp, - strand Genetic Position: Chr8, 10.78 cM
• Alliance: Atp7b^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250742
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites and an frt-flanked neomycin selection cassette were inserted at sites flanking exon 2. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:250742)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp7b Mutation: 84 strains or lines available

References

• Original: J:250742 Muchenditsi A, et al., Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice. Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1;313(1):G39-G49
• All: 2 reference(s)