Ube2o^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Ube2o^tm1.1Itl
• Name: ubiquitin-conjugating enzyme E2O; targeted mutation 1.1, Ingenious Targeting Laboratory
• MGI ID: MGI:6356787
• Synonyms: Ube2o^fl
• Gene: Ube2o Location: Chr11:116428566-116472273 bp, - strand Genetic Position: Chr11, 81.42 cM
• Alliance: Ube2o^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278266
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into the introns flanking exons 16~18, along with a Neo cassette flanked by Frt sites as a selectable marker. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:278266)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ube2o Mutation: 57 strains or lines available

References

• Original: J:278266 Vila IK, et al., A muscle-specific UBE2O/AMPKalpha2 axis promotes insulin resistance and metabolic syndrome in obesity. JCI Insight. 2019 Jul 11;4(13)
• All: 1 reference(s)