Ripk3^tm3.1Vmd
Targeted Allele Detail

Summary

• Symbol: Ripk3^tm3.1Vmd
• Name: receptor-interacting serine-threonine kinase 3; targeted mutation 3.1, Vishva M Dixit
• MGI ID: MGI:6356682
• Synonyms: Ripk3^RHIM
• Gene: Ripk3 Location: Chr14:56022452-56026314 bp, - strand Genetic Position: Chr14, 28.19 cM, cytoband C1
• Alliance: Ripk3^tm3.1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242990
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: Sequence 5'-GTGCAGATTGGG-3', encoding RIP homotypic interaction motif (RHIM) residues VQIG, was replaced with the sequence 5'-GCAGCCGCGGCT-3', coding for AAAA. An FRT site flanked neomycin selection cassette inserted into intron 9 at position chr14:55,785,501 (GRCm38, reverse strand) was deleted from the targeted embryonic stem cells before microinjection. (J:242990)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk3 Mutation: 34 strains or lines available

References

• Original: J:242990 Newton K, et al., RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. 2016 Dec 01;540(7631):129-133
• All: 1 reference(s)