Zpld1^cwh
Spontaneous Allele Detail

Summary

• Symbol: Zpld1^cwh
• Name: zona pellucida like domain containing 1; circler with hearing
• MGI ID: MGI:6356634
• Gene: Zpld1 Location: Chr16:55045538-55118349 bp, - strand Genetic Position: Chr16, 33.65 cM
• Alliance: Zpld1^cwh page

Mutation origin

• Strain of Origin: B6.129P2-Nos2^tm1Lau/J

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Single point mutation
• Mutation details: A single point mutation in exon 4, c.155A>T, changes an AAG codon to AUG changing a lysine to methionine at residue 52 (p.K52M), which is in the zona pelucida domain. (J:278455)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zpld1 Mutation: 26 strains or lines available

References

• Original: J:278455 Vijayakumar S, et al., Spontaneous mutations of the Zpld1 gene in mice cause semicircular canal dysfunction but do not impair gravity receptor or hearing functions. Sci Rep. 2019 Aug 27;9(1):12430
• All: 1 reference(s)