Cd274^em2Okat
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cd274^em2Okat
• Name: CD274 antigen; endonuclease-mediated mutation 2, Taku Okazaki
• MGI ID: MGI:6356541
• Synonyms: Cd274^Y56A
• Gene: Cd274 Location: Chr19:29344855-29365495 bp, + strand Genetic Position: Chr19, 23.88 cM, cytoband C2
• Alliance: Cd274^em2Okat page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR mediated recombination introduced two nucleotide substitutions of a TA to GC resulting in a Y56A missense mutation. This mutation prevents the formation of the cis-CD274/CD80 duplex. (J:277405)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd274 Mutation: 71 strains or lines available

References

• Original: J:277405 Sugiura D, et al., Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses. Science. 2019 May 10;364(6440):558-566
• All: 1 reference(s)