Cd80^em1Okat
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cd80^em1Okat
• Name: CD80 antigen; endonuclease-mediated mutation 1, Taku Okazaki
• MGI ID: MGI:6356535
• Synonyms: Cd80-
• Gene: Cd80 Location: Chr16:38277793-38316682 bp, + strand Genetic Position: Chr16, 26.86 cM, cytoband B5
• Alliance: Cd80^em1Okat page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR mediated recombination introduced a single nucleotide insertion of a G resulting in a frame shift after G108, the addition of 20 irrelevant amino acids, and the generation of a premature stop codon. (J:277405)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd80 Mutation: 42 strains or lines available

References

• Original: J:277405 Sugiura D, et al., Restriction of PD-1 function by cis-PD-L1/CD80 interactions is required for optimal T cell responses. Science. 2019 May 10;364(6440):558-566
• All: 1 reference(s)