Rcn3^tm1Rzm
Targeted Allele Detail

Summary

• Symbol: Rcn3^tm1Rzm
• Name: reticulocalbin 3, EF-hand calcium binding domain; targeted mutation 1, Runlin Z Ma
• MGI ID: MGI:6356297
• Synonyms: Rcn3^-
• Gene: Rcn3 Location: Chr7:44732337-44741645 bp, - strand Genetic Position: Chr7, 29.11 cM
• Alliance: Rcn3^tm1Rzm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265611
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neomycin selection cassette. Quantitative RT-PCR analysis revealed a significant reduction of mRNA levels in E18.5 homozygous mutant lungs. Western blot analysis and immunohistochemistry confirmed the absence of protein expression in E18.5 mutant lungs. (J:265611)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rcn3 Mutation: 14 strains or lines available

References

• Original: J:265611 Jin J, et al., Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. Am J Respir Cell Mol Biol. 2016 Mar;54(3):410-23
• All: 2 reference(s)