Ntn1^tm1.2Ache
Targeted Allele Detail

Summary

• Symbol: Ntn1^tm1.2Ache
• Name: netrin 1; targeted mutation 1.2, Alain Chedotal
• MGI ID: MGI:6356048
• Synonyms: Netrin-1^-
• Gene: Ntn1 Location: Chr11:68100190-68277652 bp, - strand Genetic Position: Chr11, 41.45 cM, cytoband B3
• Alliance: Ntn1^tm1.2Ache page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249067
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated recombination of flanking loxP sites resulted in the deletion of the coding sequences containing both the principal ATG (Based on Ntn1 cDNA sequence NM_008744) and the cryptic ATG (Based on Ntn1 cDNA: BC141294) and the alternative promoter in intron 3. (J:249067)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntn1 Mutation: 107 strains or lines available

References

• Original: J:249067 Dominici C, et al., Floor-plate-derived netrin-1 is dispensable for commissural axon guidance. Nature. 2017 May 18;545(7654):350-354
• All: 1 reference(s)