Ntn1^tm1.1Ache
Targeted Allele Detail

Summary

• Symbol: Ntn1^tm1.1Ache
• Name: netrin 1; targeted mutation 1.1 Alain Chedotal
• MGI ID: MGI:6356047
• Synonyms: Netrin-1^L
• Gene: Ntn1 Location: Chr11:68100190-68277652 bp, - strand Genetic Position: Chr11, 41.45 cM, cytoband B3
• Alliance: Ntn1^tm1.1Ache page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249067
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Two Loxp sites were inserted, flanking the coding sequences containing both the principal ATG (Based on Ntn1 cDNA sequence NM_008744) and the cryptic ATG (Based on Ntn1 cDNA: BC141294) and the alternative promoter in intron 3. In addition, a FRT-flanked Neomycin cassette was inserted in 5 to the LoxP-flanked region. FLP-mediated recombination resulted in the deletion of the loxP flanked selection cassette. (J:249067)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntn1 Mutation: 107 strains or lines available

References

• Original: J:249067 Dominici C, et al., Floor-plate-derived netrin-1 is dispensable for commissural axon guidance. Nature. 2017 May 18;545(7654):350-354
• All: 9 reference(s)