Ret^{tm4.1(RET)Heno}
Targeted Allele Detail

Summary

• Symbol: Ret^{tm4.1(RET)Heno}
• Name: ret proto-oncogene; targeted mutation 4.1, Hideki Enomoto
• MGI ID: MGI:6356000
• Synonyms: RET⁵¹, Retflox RET51 mCherry
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^{tm4.1(RET)Heno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275428
• Parent Cell Line: EB3 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A gene cassette composed of floxed human RET gene cDNA, an SV40 intron polyA followed by mCherry reporter gene and a neomycin resistance marker (Neo) that was flanked by FRT sites was inserted into the first coding exon of the mouse Ret gene. The neomycin resistance cassette was removed via FLP-mediated recombination in the germline. (J:275428)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 52 strains or lines available

References

• Original: J:275428 Okamoto M, et al., Mice conditionally expressing RET(C618F) mutation display C cell hyperplasia and hyperganglionosis of the enteric nervous system. Genesis. 2019 May;57(5):e23292
• All: 2 reference(s)