Cxcl12^tm1.2Spo
Targeted Allele Detail

Summary

• Symbol: Cxcl12^tm1.2Spo
• Name: C-X-C motif chemokine ligand 12; targeted mutation 1.2, S Paul Oh
• MGI ID: MGI:6355999
• Synonyms: Cxcl12^1loxP(1f)
• Gene: Cxcl12 Location: Chr6:117145496-117158328 bp, + strand Genetic Position: Chr6, 54.81 cM, cytoband F1
• Alliance: Cxcl12^tm1.2Spo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275512
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An frt-SD/SA-IRES-LacZ-Neo-frt-loxP (LacZ/Neo) cassette including a reporter (LacZ) and a positive selection marker was inserted 923-bp downstream of exon 2. A loxP sequence was cloned 278-bp upstream of exon 2. Cre-mediated recombination of flanking loxP sites resulted in deletino of exon 2 and the lacZ/neo cassette. (J:275512)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cxcl12 Mutation: 24 strains or lines available

References

• Original: J:275512 Kim BG, et al., CXCL12-CXCR4 signalling plays an essential role in proper patterning of aortic arch and pulmonary arteries. Cardiovasc Res. 2017 Nov 1;113(13):1677-1687
• All: 1 reference(s)