Slc9a3^tm1.1Sole
Targeted Allele Detail

Summary

• Symbol: Slc9a3^tm1.1Sole
• Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3; targeted mutation 1.1, Manoocher Soleimani
• MGI ID: MGI:6355978
• Synonyms: NHE3^fl
• Gene: Slc9a3 Location: Chr13:74269576-74317561 bp, + strand Genetic Position: Chr13, 40.15 cM
• Alliance: Slc9a3^tm1.1Sole page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274150
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted in positions flanking exons 4 and 5. An frt-flanked neomycin selection casssette was removed via FLP-mediated recombination in the germline. (J:274150)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc9a3 Mutation: 45 strains or lines available

References

• Original: J:274150 Li HC, et al., Proximal tubule specific knockout of the Na(+)/H(+) exchanger NHE3: effects on bicarbonate absorption and ammonium excretion. J Mol Med (Berl). 2013 Aug;91(8):951-63
• All: 9 reference(s)