Pik3c2b^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Pik3c2b^tm1.1Arte
• Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; targeted mutation 1.1 TaconicArtemis
• MGI ID: MGI:6355464
• Synonyms: C2beta^D1212A
• Gene: Pik3c2b Location: Chr1:132973410-133036429 bp, + strand Genetic Position: Chr1, 57.75 cM
• Alliance: Pik3c2b^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252034
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: The genomic DNA encoding the aspartic acid residue at codon 1212 (D1212) in the conserved ATP-binding DFG motif of the encoded protein was mutated to a codon specifying alanine. This mutation is expected to abolish the kinase activity of the protein. (J:252034)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3c2b Mutation: 81 strains or lines available

References

• Original: J:252034 Alliouachene S, et al., Inactivation of the Class II PI3K-C2beta Potentiates Insulin Signaling and Sensitivity. Cell Rep. 2015 Dec 1;13(9):1881-94
• All: 3 reference(s)