Sec13^tm1Bmaf
Targeted Allele Detail

Summary

• Symbol: Sec13^tm1Bmaf
• Name: SEC13 homolog, nuclear pore and COPII coat complex component; targeted mutation 1, Beatriz Fontoura
• MGI ID: MGI:6343532
• Synonyms: Sec13^H
• Gene: Sec13 Location: Chr6:113705013-113717642 bp, - strand Genetic Position: Chr6, 52.84 cM, cytoband E3
• Alliance: Sec13^tm1Bmaf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250176
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted downstream of the 3' end of exon 9 and is flanked by two loxP sites. A single loxP site was also inserted upstream the 5 end of exon 7. This allele expresses a lowered amount of full-length Sec13 mRNA and protein levels. This is likely due to the inclusion of the neomycin selection casette. This effect generates a certain amount of truncated protein that is likely degraded but also yields the full-length transcript. (J:250176)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sec13 Mutation: 18 strains or lines available

References

• Original: J:250176 Moreira TG, et al., Sec13 Regulates Expression of Specific Immune Factors Involved in Inflammation In Vivo. Sci Rep. 2015 Dec 3;5:17655
• All: 2 reference(s)