Etaa1^m1Anu
Chemically induced Allele Detail

Summary

• Symbol: Etaa1^m1Anu
• Name: Ewing tumor-associated antigen 1; mutation 1, Australian National University
• MGI ID: MGI:6343404
• Synonyms: Etaa1^deltaEx2
• Gene: Etaa1 Location: Chr11:17888756-17903875 bp, - strand Genetic Position: Chr11, 10.44 cM
• Alliance: Etaa1^m1Anu page

Mutation origin

• Strain of Origin: C57BL/6NCrl
• Project Collection: APF ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is a point mutation in the intron between exons 2 and 3, predicted to be damaging because it substitutes a C nucleotide for the essential +2 T of the splice donor consensus sequence. Mutant transcripts show several aberrant splicing patterns, all of which result in a frame-shift and premature stop codons. This exon 2 skipping allele deletes Gly78-Leu119. (J:244584)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Etaa1 Mutation: 47 strains or lines available

References

• Original: J:244584 Miosge LA, et al., Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5216-E5225
• All: 1 reference(s)