Lpin3^tm1Reue
Targeted Allele Detail

Summary

• Symbol: Lpin3^tm1Reue
• Name: lipin 3; targeted mutation 1, Karen Reue
• MGI ID: MGI:6343243
• Synonyms: Lpin3 KO
• Gene: Lpin3 Location: Chr2:160722590-160747920 bp, + strand Genetic Position: Chr2, 80.98 cM
• Alliance: Lpin3^tm1Reue page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220917
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A promoterless beta-geo cassette (a fusion of beta-galactosidase and neomycin resistance genes) was introduced into intron 3. A fusion trasncript is expressed that contains the first three exons fused to the Beta-geo gene. No detectable wild-type transcript or protein is made from this allele. (J:220917)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lpin3 Mutation: 50 strains or lines available

References

• Original: J:220917 Csaki LS, et al., Lipin-1 and lipin-3 together determine adiposity in vivo. Mol Metab. 2014 Apr;3(2):145-54
• All: 2 reference(s)