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Lrp4tm1.1Pg
Targeted Allele Detail
Nomenclature
Symbol: Lrp4tm1.1Pg
Name: low density lipoprotein receptor-related protein 4; targeted mutation 1.1, PolyGene AG
MGI ID: MGI:6343233
Synonyms: Lrp4R1170Q
Gene: Lrp4  Location: Chr2:91287856-91344124 bp, + strand  Genetic Position: Chr2, 50.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:277372
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Single point mutation
 
Mutation detailsA G to A change at position 3509 resulting in an arginine to glutamine change at amino acid 1170 (R1170Q) was introduced in exon 25. An FRT-flanked neomycin cassette was inserted 418 bp downstream of exon 25 and was excised via Flp-mediated recombination. (J:277372)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrp4 Mutation:  60 strains or lines available
References
Original:  J:277372 Boudin E, et al., The Lrp4R1170Q Homozygous Knock-In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans. J Bone Miner Res. 2017 Aug;32(8):1739-1749
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory