Nrdc^tm2.1Eiin
Targeted Allele Detail

Summary

• Symbol: Nrdc^tm2.1Eiin
• Name: nardilysin convertase; targeted mutation 2.1, Eiichiro Nishi
• MGI ID: MGI:6343086
• Synonyms: Nrd1^flox
• Gene: Nrdc Location: Chr4:108857852-108918974 bp, + strand Genetic Position: Chr4, 50.77 cM
• Alliance: Nrdc^tm2.1Eiin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247243
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and FRT-flanked neomycin selection cassette were inserted upstream of exon 1 and a loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the selection cassette leaving exon 1 floxed. (J:247243)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrdc Mutation: 35 strains or lines available

References

• Original: J:247243 Nishi K, et al., Nardilysin Is Required for Maintaining Pancreatic beta-Cell Function. Diabetes. 2016 Oct;65(10):3015-27
• All: 4 reference(s)