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Mirc21tm1Doca
Targeted Allele Detail
Summary
Symbol: Mirc21tm1Doca
Name: microRNA cluster 21, including Mir34c through Mir34b; targeted mutation 1, Donal O'Carroll
MGI ID: MGI:6342925
Synonyms: mir-34bc FLOX
Gene: Mirc21  Location: Chr9:51014334-51014945 bp  Genetic Position: Chr9, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:228491
Parent Cell Line:  A9 (ES Cell)
Strain of Origin:  (C57BL/6 x 129P2/OlaHsd)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of the pre-Mir34b seqeunce. An additional loxP site was inserted downstream of the pre-Mir34c sequence. (J:228491)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mirc21 Mutation:  5 strains or lines available
References
Original:  J:228491 Comazzetto S, et al., Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 loci. PLoS Genet. 2014 Oct;10(10):e1004597
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory