Nkiras1^tm1.1Gho
Targeted Allele Detail

Summary

• Symbol: Nkiras1^tm1.1Gho
• Name: NFKB inhibitor interacting Ras-like protein 1; targeted mutation 1.1, Sankar Ghosh
• MGI ID: MGI:6342804
• Synonyms: KO allele
• Gene: Nkiras1 Location: Chr14:4185693-4198560 bp, - strand Genetic Position: Chr14, 7.08 cM, cytoband A3
• Alliance: Nkiras1^tm1.1Gho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277582
• Parent Cell Line: CT129 (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP-flanked neomycin selection cassette was inserted 5' to exon 2, and a third lox P site was inserted 3' to exon 3. Cre-mediated recombination removed exons 2 and 3. (J:277582)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkiras1 Mutation: 15 strains or lines available

References

• Original: J:277582 Oeckinghaus A, et al., kappaB-Ras proteins regulate both NF-kappaB-dependent inflammation and Ral-dependent proliferation. Cell Rep. 2014 Sep 25;8(6):1793-1807
• All: 2 reference(s)