Cd276^tm1.1Bstc
Targeted Allele Detail

Summary

• Symbol: Cd276^tm1.1Bstc
• Name: CD276 antigen; targeted mutation 1.1, Brad St Croix
• MGI ID: MGI:6342763
• Gene: Cd276 Location: Chr9:58431583-58462316 bp, - strand Genetic Position: Chr9, 31.79 cM
• Alliance: Cd276^tm1.1Bstc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242494
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassete with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. (J:242494)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd276 Mutation: 22 strains or lines available

References

• Original: J:242494 Seaman S, et al., Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature. Cancer Cell. 2017 Apr 10;31(4):501-515.e8
• All: 1 reference(s)