Recql4^em1Crwy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Recql4^em1Crwy
• Name: RecQ protein-like 4; endonuclease-mediated mutation 1, Carl R Walkley
• MGI ID: MGI:6342633
• Synonyms: Recql4^K525A, Recql4^tm4Crw
• Gene: Recql4 Location: Chr15:76587753-76594748 bp, - strand Genetic Position: Chr15, 36.28 cM, cytoband D3
• Alliance: Recql4^em1Crwy page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated an AAG to GCA change resulting in a lysine to alanine mutation at amino acid 525 (K525A). This mutation abolishes ATP-dependent helicase activity. (J:277473)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Recql4 Mutation: 49 strains or lines available

References

• Original: J:277473 Castillo-Tandazo W, et al., ATP-dependent helicase activity is dispensable for the physiological functions of Recql4. PLoS Genet. 2019 Jul;15(7):e1008266
• All: 2 reference(s)