Il31ra^em2Phep
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il31ra^em2Phep
• Name: interleukin 31 receptor A; endonuclease-mediated mutation 2, Paul A Heppenstall
• MGI ID: MGI:6342541
• Synonyms: Il31ra^S476F
• Gene: Il31ra Location: Chr13:112649439-112717266 bp, - strand Genetic Position: Chr13, 63.75 cM
• Alliance: Il31ra^em2Phep page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a point mutation within exon 14 resulting in an amino acid substitution in position 476 of a serine with a phenylalanine. (J:277431)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il31ra Mutation: 82 strains or lines available

References

• Original: J:277431 Nocchi L, et al., Interleukin-31-mediated photoablation of pruritogenic epidermal neurons reduces itch-associated behaviours in mice. Nat Biomed Eng. 2019 Feb;3(2):114-125
• All: 1 reference(s)