Ccno^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Ccno^{tm1.1(KOMP)Vlcg}
• Name: cyclin O; targeted mutation 1.1, Velocigene
• MGI ID: MGI:6342444
• Synonyms: Ccno delta
• Gene: Ccno Location: Chr13:113124363-113127313 bp, + strand Genetic Position: Chr13, 63.93 cM
• Alliance: Ccno^{tm1.1(KOMP)Vlcg} page
• IMPC: Ccno gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256010
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated excision of the parental Ccno^{tm1(KOMP)Vlcg} allele resulted in the removal of the neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:256010)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccno Mutation: 19 strains or lines available

References

• Original: J:256010 Nunez-Olle M, et al., Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility. Oncotarget. 2017 Nov 21;8(59):99261-99273
• All: 3 reference(s)