Mirc10tm1Rdf
Targeted Allele Detail
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| Symbol: |
Mirc10tm1Rdf |
| Name: |
microRNA cluster 10, including Mir15b through Mir16-2; targeted mutation 1, Riccardo Dalla-Favera |
| MGI ID: |
MGI:6342252 |
| Synonyms: |
miR-15b/16-2 KO |
| Gene: |
Mirc10 Location: unknown Genetic Position: Chr3, Syntenic
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| Germline Transmission: |
Earliest citation of germline transmission:
J:226920
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The miR-15b/16-2 hairpin spans 430 bp. To generate the miR-15b/16-2 KO targeting vector, DNA fragments flanking miRNAs, with a NotI-BamHI fragment (3.4 kb) as the 5 arm and a HindIII-EcoRI fragment (1.3 kb) as the 3 arm, were isolated from a 129/Sv genomic library and subcloned into a pflox vector. Two selectable markers are incorporated into this vector. The neomycin resistance gene (neo) is flanked by loxP sites and located between the two arms.
(J:226920)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mirc10 Mutation: |
4 strains or lines available
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| Original: |
J:226920 Lovat F, et al., miR-15b/16-2 deletion promotes B-cell malignancies. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11636-41 |
| All: |
2 reference(s) |
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Analysis Tools
