Gsdmd^em1Tdk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gsdmd^em1Tdk
• Name: gasdermin D; endonuclease-mediated mutation 1, Thirumala-Devi Kanneganti
• MGI ID: MGI:6342025
• Gene: Gsdmd Location: Chr15:75734176-75739257 bp, + strand Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
• Alliance: Gsdmd^em1Tdk page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: The null allele was engineered using CRISPR/Cas9 technology, through which a small out-of-frame insertion was created. (J:262477)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdmd Mutation: 32 strains or lines available

References

• Original: J:262477 Karki R, et al., IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Cell. 2018 May 3;173(4):920-933.e13
• All: 11 reference(s)