Tg(ACTA1-Ppargc1a_ia)BOse
Transgene Detail

Summary

• Symbol: Tg(ACTA1-Ppargc1a_ia)BOse
• Name: transgene insertion B, Osamu Ezaki
• MGI ID: MGI:6324951
• Transgene: Tg(ACTA1-Ppargc1a_ia)BOse Location: unknown
• Alliance: Tg(ACTA1-Ppargc1a_ia)BOse page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/1)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Modified isoform(s))
• Mutation: Insertion
• Tg(ACTA1-Ppargc1a_ia)BOse expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppargc1a (MGI:1342774)	Human promoter and mouse isoform a cDNA

• Mutation details: The transgene contains the following elements: a 2.2 kb DNA fragment containing the promoter, exon 1 and (part of) intron 1 of the human skeletal muscle actin alpha 1 gene, the a isoform cDNA of the mouse peroxisome proliferative activated receptor gamma coactivator 1 alpha gene, and bovine growth hormone poly(A) signal sequences. The a splice variant incorporates alternative 5' exon 1a. Six mouse lines were established and lines B, D, and E were studied. (J:84880)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:84880 Miura S, et al., Overexpression of peroxisome proliferator-activated receptor gamma coactivator-1alpha down-regulates GLUT4 mRNA in skeletal muscles. J Biol Chem. 2003 Aug 15;278(33):31385-90
• All: 1 reference(s)