Brd7^{tm2c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Brd7^{tm2c(EUCOMM)Wtsi}
• Name: bromodomain containing 7; targeted mutation 2c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6323641
• Gene: Brd7 Location: Chr8:89057667-89088822 bp, - strand Genetic Position: Chr8, 43.07 cM, cytoband C4
• Alliance: Brd7^{tm2c(EUCOMM)Wtsi} page
• IMPC: Brd7 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276819
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt2 cassette was inserted at position 89080973 of Chromosome 8 upstream of exon 5 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of exon 5 at position 89081942. Exon 5 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. (J:276819)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Brd7 Mutation: 32 strains or lines available

References

• Original: J:276819 Lee JM, et al., BRD7 deficiency leads to the development of obesity and hyperglycemia. Sci Rep. 2019 Mar 29;9(1):5327
• All: 2 reference(s)