Ppp2ca^tm1.1Lsun
Targeted Allele Detail

Summary

• Symbol: Ppp2ca^tm1.1Lsun
• Name: protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; targeted mutation 1.1, Lei Sun
• MGI ID: MGI:6323588
• Synonyms: PP2A Calpha-deltaneo-fl, PP2ACalpha^f
• Gene: Ppp2ca Location: Chr11:51989651-52013576 bp, + strand Genetic Position: Chr11, 31.86 cM
• Alliance: Ppp2ca^tm1.1Lsun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276373
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 was flanked by loxP sites and an FRT-flanked neomycin selection cassette was inserted downstream of the floxed exon 1. Flp-mediated recombination removed the neomycin cassette, leaving exon 1 foxed. (J:276373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp2ca Mutation: 26 strains or lines available

References

• Original: J:276373 Sun L, et al., Myeloid-Specific Gene Deletion of Protein Phosphatase 2A Magnifies MyD88- and TRIF-Dependent Inflammation following Endotoxin Challenge. J Immunol. 2017 Jan 1;198(1):404-416
• All: 2 reference(s)