Tg(CAG-HPSE*)#Jpli
Transgene Detail

Summary

• Symbol: Tg(CAG-HPSE*)#Jpli
• Name: transgene insertion, Jin-Ping Li
• MGI ID: MGI:6323437
• Synonyms: Hpa-tg, tgHpa
• Transgene: Tg(CAG-HPSE*)#Jpli Location: unknown
• Alliance: Tg(CAG-HPSE*)#Jpli page

Transgene origin

• Strain of Origin: C57BL x BALB/c

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-HPSE*)#Jpli expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HPSE (10855)

  Hpse	(MGI:1343124)

  Human cDNA with chicken signal peptide sequence

• Mutation details: The transgene construct contains a modified full-length human cDNA inserted between the CAG promoter/enhancer and rabbit beta-globin poly(A) signal sequences. To enhance secretion of the encoded peptide, the cDNA was modified by replacing the human signal peptide sequence with that of the chicken ortholog. (J:276687)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:276687 Zhang X, et al., Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-beta in murine brain. Acta Neuropathol. 2012 Oct;124(4):465-78
• All: 4 reference(s)