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Stxbp1tm1Ksak
Targeted Allele Detail
Nomenclature
Symbol: Stxbp1tm1Ksak
Name: syntaxin binding protein 1; targeted mutation 1, Kenji Sakimura
MGI ID: MGI:6322965
Synonyms: Munc18-1 floxed, Stxbp1 floxed
Gene: Stxbp1  Location: Chr2:32787607-32847237 bp, - strand  Genetic Position: Chr2, 22.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:252714
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA neomycin-resistance cassette flanked by two frt sites was inserted into the site 162 bp upstream of the exon 3, and a second loxP sequence was inserted into the site 159 bp downstream of the exon 3. (J:252714)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stxbp1 Mutation:  4 strains or lines available
References
Original:  J:252714 Miyamoto H, et al., Potentiation of excitatory synaptic transmission ameliorates aggression in mice with Stxbp1 haploinsufficiency. Hum Mol Genet. 2017 Dec 15;26(24):4961-4974
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory