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Endonuclease-mediated Allele Detail
Symbol: Dennd5bem1Smgo
Name: DENN/MADD domain containing 5B; endonuclease-mediated mutation 1, Scott M Gordon
MGI ID: MGI:6317361
Synonyms: Dennd5b-
Gene: Dennd5b  Location: Chr6:148889569-149003178 bp, - strand  Genetic Position: Chr6, 78.71 cM
Strain of Origin:  (C57BL/6 x CBA)F1
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsUsing custom zinc finger nucleases, exons in the 5' one-third of the gene were targeted. ZFN RNA was microinjected into pronuclei of fertilized B6CBAF1 mouse embryos. This led to the establishment of a line with a biallelic 19 bp deletion (GGGTCTTCAGTCAAAAGAA) in exon 4 in the DENN domain of the encoded peptide. (J:276600)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dennd5b Mutation:  179 strains or lines available
Original:  J:276600 Gordon SM, et al., DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass. Sci Rep. 2019 Mar 5;9(1):3597
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
The Jackson Laboratory