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Endonuclease-mediated Allele Detail
Symbol: Thraem6Ffla
Name: thyroid hormone receptor alpha; endonuclease-mediated mutation 6, Frederic Flamant
MGI ID: MGI:6317007
Synonyms: ThraSlox, TRalphaS3
Gene: Thra  Location: Chr11:98741776-98769006 bp, + strand  Genetic Position: Chr11, 62.58 cM, cytoband D-E
Strain of Origin:  129
Allele Type:    Endonuclease-mediated (Conditional ready, Reporter)
Mutation:    Undefined
Mutation detailsCRISPR-targeting in embryos carrying Thratm1Ffla with a 5' floxed neo cassette, a cDNA encoding the open reading frame with a nucleotide substitution that results in an amino acid substitution of arginine for leucine at position 400 (L400R), and a 3' IRES-Tau-lacZ cassette resulted in a frameshift mutation after position 393 and a gain of stop codon at position 401. (J:268664)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thra Mutation:  15 strains or lines available
Original:  J:268664 Markossian S, et al., CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone. Thyroid. 2018 Jan;28(1):139-150
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory