Hprt1^{tm9(CAG-SPHK2)Geno}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm9(CAG-SPHK2)Geno}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 9, Genoway
• MGI ID: MGI:6316638
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm9(CAG-SPHK2)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248835
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Hprt1^{tm9(CAG-SPHK2)Geno} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SPHK2 (56848)

  Sphk2

  (MGI:1861380)

• Mutation details: The targeting construct introduced into the locus a CAG promoter, a floxed stop cassette, and a the human SPHK2 sequence. Following cre-mediated recombination, the human protein is produced. (J:248835)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:248835 Schwalm S, et al., Sphingosine Kinase-2 Deficiency Ameliorates Kidney Fibrosis by Up-Regulating Smad7 in a Mouse Model of Unilateral Ureteral Obstruction. Am J Pathol. 2017 Nov;187(11):2413-2429
• All: 1 reference(s)