Lrrk2^tm1.1Hosl
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm1.1Hosl
• Name: leucine-rich repeat kinase 2; targeted mutation 1.1, Shu-Leong Ho
• MGI ID: MGI:6315902
• Synonyms: LRRK2^R1441G
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm1.1Hosl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274953
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: An FRT flanked neo cassette was inserted in intron 30 and an R1441G (c.4321C>G) mutation was introduced in exon 31 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:274953)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 163 strains or lines available

References

• Original: J:274953 Liu HF, et al., LRRK2 R1441G mice are more liable to dopamine depletion and locomotor inactivity. Ann Clin Transl Neurol. 2014 Mar;1(3):199-208
• All: 4 reference(s)