Nptn^tm1Qyu
Targeted Allele Detail

Summary

• Symbol: Nptn^tm1Qyu
• Name: neuroplastin; targeted mutation 1, Qionglan Yuan
• MGI ID: MGI:6315866
• Synonyms: NP65^-
• Gene: Nptn Location: Chr9:58489504-58560162 bp, + strand Genetic Position: Chr9, 31.79 cM
• Alliance: Nptn^tm1Qyu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276256
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Modified isoform(s))
• Mutation: Insertion
• Mutation details: The targeting vector was constructed by inserting translation stop codon TAATAA into exon 2 which results in stop of translation of exon 2 therefore deleting the Ig1 domain and inserting loxP and FRT-neo-FRT-loxP cassette into exon 3 upstream and downstream, respectively. Western blot analysis indicates that only the NP55 isoform and not the NP66 isoform is expressed in the forebrain of homozygous mice. (J:276256)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nptn Mutation: 40 strains or lines available

References

• Original: J:276256 Amuti S, et al., Neuroplastin 65 mediates cognitive functions via excitatory/inhibitory synapse imbalance and ERK signal pathway. Neurobiol Learn Mem. 2016 Jan;127:72-83
• All: 5 reference(s)