Acsl5^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Acsl5^tm1.2Geno
• Name: acyl-CoA synthetase long-chain family member 5; targeted mutation 1.2, Genoway
• MGI ID: MGI:6315487
• Gene: Acsl5 Location: Chr19:55240298-55285060 bp, + strand Genetic Position: Chr19, 51.3 cM, cytoband D2
• Alliance: Acsl5^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269639
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 16. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 18. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 16 and 17 floxed. (J:269639)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acsl5 Mutation: 54 strains or lines available

References

• Original: J:269639 Bowman TA, et al., Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption. Mol Metab. 2016 Mar;5(3):210-220
• All: 1 reference(s)