Tnfrsf4^{tm1.1(TNFRSF4)Geno}
Targeted Allele Detail

Summary

• Symbol: Tnfrsf4^{tm1.1(TNFRSF4)Geno}
• Name: tumor necrosis factor receptor superfamily, member 4; targeted mutation 1.1, Genoway
• MGI ID: MGI:6315468
• Synonyms: hOX40, Tnfrsf4^{tm1.1(hTNFRSF4)Geno}, Tnfrsf4^{tm1(TNFRSF4-ICP2)Geno}
• Gene: Tnfrsf4 Location: Chr4:156098300-156101069 bp, + strand Genetic Position: Chr4, 87.68 cM
• Alliance: Tnfrsf4^{tm1.1(TNFRSF4)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276209
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Tnfrsf4^{tm1.1(TNFRSF4)Geno} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TNFRSF4 (7293)

  Tnfrsf4

  (MGI:104512)

• Mutation details: The human extracellular, transmembrane and intracellular domains replaced the mouse sequence. Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:276209)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf4 Mutation: 33 strains or lines available

Notes

https://www.genoway.com/services/catalog/humanized-mouse/immune-checkpoints.htm

References

• Original: J:276209 Sonego F, Direct Data Submission for Genoway Humanized Immune Checkpoint (ICP) Mice. MGI Direct Data Submission. 2019
• All: 1 reference(s)