Pink1^tm1Hxz
Targeted Allele Detail

Summary

• Symbol: Pink1^tm1Hxz
• Name: PTEN induced putative kinase 1; targeted mutation 1, Hui Zhang
• MGI ID: MGI:6315258
• Gene: Pink1 Location: Chr4:138040720-138053618 bp, - strand Genetic Position: Chr4, 70.14 cM
• Alliance: Pink1^tm1Hxz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276160
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ reporter and neomycin resistance cassette replaced exons 2 through 5. Western blot analysis confirmed the absence of protein. (J:276160)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pink1 Mutation: 43 strains or lines available

References

• Original: J:276160 Zhi L, et al., Loss of PINK1 causes age-dependent decrease of dopamine release and mitochondrial dysfunction. Neurobiol Aging. 2019 Mar;75:1-10
• All: 6 reference(s)