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Tg(Vav1-Asxl1*Y588X)#Fcy
Transgene Detail
Nomenclature
Symbol: Tg(Vav1-Asxl1*Y588X)#Fcy
Name: transgene insertion, Feng-Chun Yang
MGI ID: MGI:6315194
Synonyms: Asxl1Y588XTg
Transgene: Tg(Vav1-Asxl1*Y588X)#Fcy  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Epitope tag, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Vav1-Asxl1*Y588X)#Fcy expresses 1 gene
 
Mutation detailsThe entire coding region of mouse Asxl1 cDNA with a TAC to TGA change resulting in a stop codon mutation on the Y588 site with a FLAG tag is under the control of the Vav1 promoter. Y558X in the mouse corresponds to human Y591X which is the most frequent nonsense mutation type in patients with malignant myeloid diseases. Western blot analysis confirmed the expression of a truncated protein. Five lines were generated, I through V. The pound symbol (#) is used when no line is specified and/or lines are pooled. J:257690 reports pooled data from lines I and II. (J:257690)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:257690 Yang H, et al., Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies. Blood. 2018 Jan 18;131(3):328-341
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory