Rnasel^em1Ptsa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rnasel^em1Ptsa
• Name: ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent); endonuclease-mediated mutation 1, Panagiotis Tsapogas
• MGI ID: MGI:6314646
• Synonyms: RNaseL^-
• Gene: Rnasel Location: Chr1:153625172-153639967 bp, + strand Genetic Position: Chr1, 65.43 cM, cytoband G2
• Alliance: Rnasel^em1Ptsa page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 328-bp deletion in exon 1 resulting in a frame shift and a premature-stop codon. (J:275319)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnasel Mutation: 26 strains or lines available

References

• Original: J:275319 Klein F, et al., The transcription factor Duxbl mediates elimination of pre-T cells that fail beta-selection. J Exp Med. 2019 Mar 4;216(3):638-655
• All: 1 reference(s)