Gt(ROSA)26Sor^tm1(MYC)Djmy
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(MYC)Djmy
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Daniel J Murphy
• MGI ID: MGI:6314550
• Synonyms: Rosa26^DM.Isl-MYC
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(MYC)Djmy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263858
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm1(MYC)Djmy expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MYC (4609)

  Myc	(MGI:97250)

  Myc2 isoform

• Mutation details: A human MYC, preceded by a floxed neo cassette with a triple polyadenylation sequence and followed by an IRES-EGFP, was inserted into the ROSA locus. Expression of the fusion product can only be achieved through cre mediated removal of the neo cassette along with its polyadenlylation sequences. (J:263858)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

References

• Original: J:263858 Kruspig B, et al., The ERBB network facilitates KRAS-driven lung tumorigenesis. Sci Transl Med. 2018 Jun 20;10(446)
• All: 4 reference(s)