Fndc5^tm1.1Brsp
Targeted Allele Detail

Summary

• Symbol: Fndc5^tm1.1Brsp
• Name: fibronectin type III domain containing 5; targeted mutation 1.1, Bruce M Spiegelman
• MGI ID: MGI:6307130
• Gene: Fndc5 Location: Chr4:129030672-129038386 bp, + strand Genetic Position: Chr4, 62.93 cM
• Alliance: Fndc5^tm1.1Brsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269575
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cre-mediated recombination removed the floxed exons 3 and 4. (J:269575)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fndc5 Mutation: 18 strains or lines available

References

• Original: J:269575 Kim H, et al., Irisin Mediates Effects on Bone and Fat via alphaV Integrin Receptors. Cell. 2018 Dec 13;175(7):1756-1768.e17
• All: 2 reference(s)